[HTML][HTML] The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation …

F Caratis, M Opiełka, M Hausmann, M Velasco-Estevez… - Plos one, 2024 - journals.plos.org
… -activated and TDAG8-mediated pathways in peritoneal macrophages by RNA-sequencing
(RNA-seq). We found that activation of TDAG8 by low pH … -term cell culture in low pH induces …

[HTML][HTML] R-Ras GTPases signaling role in myelin neurodegenerative diseases

B Alcover-Sanchez, G Garcia-Martin… - International Journal of …, 2020 - mdpi.com
… major pathways involved in myelination (PI3K/Akt/mTOR, ERK1/2-… ) and MBP in myelinating
co-cultures of constitutively active MEK (… Wnt/β-catenin route through downstream effectors. …

Rab11a Controls Cell Shape via C9orf72 Protein: Possible Relationships to Frontotemporal Dementia/Amyotrophic Lateral Sclerosis (FTDALS) Type 1

S Fukatsu, H Sashi, R Shirai, N Takagi, H Oizumi… - Pathophysiology, 2024 - mdpi.com
… cell line, were cultured on cell culture dishes in DMEM/F-12 … To investigate whether Rab11a,
the major C9orf72 effector, … through activation of the MAPK pathway in cultured cortical …

[HTML][HTML] Hydrogen ion dynamics as the fundamental link between neurodegenerative diseases and cancer: Its application to the therapeutics of neurodegenerative …

S Harguindey, K Alfarouk, J Polo Orozco… - International Journal of …, 2022 - mdpi.com
pH acts as a fundamental factor in controlling oligodendrocyte maturation via the
activation of the ERK1/2 in pathway in culture [252]. The optimal pHi for OPC …

The proton-activated receptor TDAG8 is upregulated in oligodendrocytes during maturation and under acidic conditions

M Opiełka, F Caratis, M Hausmann, M Velasco-Estevez… - bioRxiv, 2023 - biorxiv.org
activated and TDAG8-mediated pathways in peritoneal macrophages by RNA sequencing.
We found that activation of TDAG8 by low pHculture in cither normal, high or low pH. The low …

[HTML][HTML] Pathways involved in remyelination after cerebral ischemia

G Garcia-Martin, B Alcover-Sanchez… - Current …, 2022 - ncbi.nlm.nih.gov
… remyelination in ischemic lesions by activation of ERK1/2 [85]. … Culture of OPCs with medium
from M2 conditioned microglia … , resulted to be the downstream effector of IL-4 signaling. …

[HTML][HTML] Nogo-A aggravates oxidative damage in oligodendrocytes

YY Wang, N Han, DJ Hong, J Zhang - Neural Regeneration …, 2021 - journals.lww.com
… (A) Cell lysates collected from oligodendrocyte cultures treated … blot analysis using
antibodies against p-ERK1/2 or t-ERK1/2. … pathways were not involved in the oxidative injury of …

The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation

S Cui, N Suo, Y Yang, X Wu, S Guo, X Xie - Acta Pharmacologica Sinica, 2024 - nature.com
… to promote OPC differentiation, in OPC culture. In conclusion, … of these pathways were tested
during OPC differentiation in … to produce two important intracellular second messengers, IP …

Novel guanidine compounds inhibit platelet‐derived growth factor receptor alpha transcription and oligodendrocyte precursor cell proliferation

J Medved, WM Wood, MD van Heyst, A Sherafat… - Glia, 2021 - Wiley Online Library
oligodendrocyte differentiation using primary OPC cultures, … on PDGFRα and its downstream
effectors. (a) Quantification of … Erk1/2 mitogen-activated protein kinase (MAPK) or phospho-…

[HTML][HTML] BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

J Zhou, N Singh, J Galske, J Hudobenko, X Hu… - Molecular …, 2023 - Springer
… and downstream P38 and ERK1/2 signaling pathways, which may … cultures were significantly
higher compared to WT controls (Fig. 1… Aβ 42 and examined intracellular Aβ levels by either …